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As expected, the total flushing volume necessary to remove the residual saturation was reduced substantially in the presence of all applied agents.
In order to successfully utilise dermal microdialysis to establish bioequivalence of topically applied agents, particular care must be applied to study design.
Taken together, the physical and chemical properties of drugs, small molecules and macromolecular carriers determine the tissue affinity of the infusate and strongly affect the distribution of locally applied agents.
Our objective was to determine whether the degree of variability associated with dermal microdialysis allows its practical application to determinations of bioequivalence of topically applied agents with a reasonable number of subjects.
Arteriolar responsiveness was assessed using ionophoretically applied agents: muscarinic agonist acetylcholine (0.025 M; ACh; 20, 40, 100, and 200 nA), and nitric oxide donor sodium nitroprusside (0.05 M; SNP; 20, 40, and 100 nA), or adrenergic agonist phenylephrine (0.05 M; PE; 20, 40, and 100 nA) using glass micropipettes.
Cisplatin is one of the most frequently applied agents in the treatment of advanced NSCLC.
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Therefore, CTG provides a novel tool to determine the possible distribution pattern of an intranasally applied agent in the brain.
Therefore, Nu-3 may represent a promising externally applied agent for treating wound infection.
U.S. Air Force veterans of Operation Ranch Hand, who applied Agent Orange in Vietnam, were exposed to dioxin.
Therefore, chlorhexidine gluconate oral rinse, an inexpensive and easily applied agent, should be a routine aspect of care of the critically ill patient.
Eyes affected were treated with a topically applied agent, among others, a combination of chlorhexidine (0.02%) and polyhexamethylene biguanide (PHMB, 0.02%), propamidine isethionate (0.1%), and antibiotic neomycin; however the treatment was without clear clinical improvement.
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CEO of Professional Science Editing for Scientists @ prosciediting.com