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Applications to sequence optimisation comprise the re-design of the protein cores of c-Crk SH3 domain, the B1 domain of protein G and Ubiquitin, and of surface residues of the SH3 domain.
The MapReduce pattern is finding increasing use in Bioinformatics [ 14], with particularly significant applications to sequence analysis [ 12, 13].
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Tables 1 and 2 provide an overview of these genome-wide methylation analysis strategies and their applications to sequencing (Table 1) and microarray (Table 2) platforms and their significant advantages and limitations.
The integration of the various datasets brings creative application to sequence stratigraphy that significantly increases the accuracy and reliability of geological interpretation.
The proposed method leads directly to the generation of the associated Ladder Logic Diagrams (LLDs) and it has proved to be effective through the application to sequence control of a small-scale industrial system.
We evaluate several IBD detection methods that are fast enough for application to sequence data (IBDseq, Beagle Refined IBD, PLINK, and GERMLINE) under multiple parameter settings, and we show that IBDseq achieves high power and accuracy for IBD detection in sequence data.
The application to sequence alignment is interesting, but not obviously useful.
For illustration, an application to sequencing optimization for heterogeneous cold-standby system is given; a modified genetic algorithm is developed to solve the proposed optimization problem with interval-valued objective.
Collyer's hypothesis may prove relevant to the perception of sequences with three or more stimulus locations, but its application to sequences with just two spatial positions, which also produce illusions (e.g., Fig. 1A), is less clear.
Additionally, collapsing methods hold great promise for the future with the application to sequencing data.
This length dependency prevents its application to sequences shorter than 1000 bp.
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