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This is one of the most promising and powerful applications of expression profiling with expression microarrays.
With the extensive applications of expression profiling, microarray analysis on miRNAs has become a fast and effective approach to detect distinctive signatures for specific tissues or disorders [ 13, 14].
Therefore, future applications of expression profiling of these genes in biopsied samples may contribute to clinical practice and may promote objective criteria for intervention, such as endoscopic mucosal resection.
Considering data analysis in this comprehensive manner is supported by the evidence observed in several applications of expression quantitative trait loci (eQTLs), including in inflammatory disease (BES), T2D (Judy Zhong, New York University Medical School), and coronary artery disease (JB).
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The cross-species application of expression microarrays is equivalent to the application of poor quality microarrays.
The application of expression microarray profiling technology promises to change both our understanding of tumor biology and our clinical practices.
Another application of expression signatures is the monitoring of transcriptome changes in a community upon exposure to a toxicant [ 22].
These findings verify diagnostic utility and application of expression data for improved selection of high-risk STS patients.
The improvement of platforms, especially the broadening application of expression microarrays and characterization of mutants with relevant phenotypes (e.g. fancl nkhg10aEt/ nkhg10aEt [ 128], nanos3 fh49/fh49 [ 129]), has allowed researchers to start looking for large-scale changes and study the involvement of major developmental pathways.
In this respect both (NB1) and (NB2) are, prima facie, more problematic than (ME1), since the application of expressions is something that is clearly within the voluntary control of S. 38.
The routine application of expression-based prognostic markers in clinical practice might be limited by the instability of mRNA in comparison with DNA, which will require strict adherence to elaborated standard operating procedures in the processing of tumor samples.
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