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Further gallic acid application trials in lentic systems such as small freshwater ponds may help to design innovative allelopathy-based aquatic ecotechnologies.
Figure 2 Samples of the stones selected for testing (left); application trials on different lithotypes (right).
A number of application trials (Figure 2b) have been carried out on all stones in order to optimize the application parameters of both compounds.
Relevant publications related to pre-market application trials were identified to learn about follow-up results.
In a questionnaire survey at Tokushima University Hospital[ 8], 61% of faculty had contributed to IND application trials and 58% of those wanted to participate in IND application trials, whereas in our survey at KUH, 89% of faculty reported past participation in clinical research.
In Japan, clinical trials of new drugs can be classified into two categories: investigational new drug (IND) application trials, and studies that do not seek marketing approval (non-notified trials).
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However, the application trial for these enzyme-immobilized membranes is still elementary.
HSW participated in developing the protocol concept, in the ethical committee application, trial coordination and patient recruitment.
HSW participated in developing the protocol concept, participated in the ethical committee application, trial coordination and patient recruitment.
19 In a 2-year long-term application trial, marked or excellent improvement or clearance of disease was reported in 90% and 93.1% of patients at weeks 10 and 104, respectively.
CT participated in protocol design, ethical committee and BfS applications, trial coordination and conduction, patient recruitment, translational studies, and wrote the manuscript together with PEH.
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