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We present in this article our contribution to the challenge of epigenomic data analysis with application to the variable response to the Hepatitis B virus (HBV) vaccine and its most lethal degeneration: hepatocellular carcinoma (HCC).
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We acknowledge that the verification procedure used does not include two important aspects for application to the field: variable abundances of species in mixtures and species-specific biases in DNA extraction.
The dimension of some of these spaces can be computed in a straightforward way, and this ends up having an application to the study of three variable rational inner functions.
The paper concludes with the description of ModGen's application to the classification of unmeasured variables of an existing medium-size process plant by means of GS-FLCN's structural technique for observability analysis.
On this basis, a Maple code is developed for full global optimization of functions of n variables with application to the finding of all roots of a polynomial, to the eigenvalue problems, and to the solution of nonlinear systems of equations, including underdetermined and overdetermined systems.
Finally, the multiobjective optimization method and its application to the optimal dispatch problem considering different variables representations are considered.
We hypothesize that these biosynthetic scaffolds could be useful in a wide variety of applications due to the variable bioactivity of the natural DECM component and the physical tunability of the synthetic polymer component.
Previously identified bladder cancer markers have been of limited utility in clinical applications owing to the variable (HRAS; Fitzgerald et al, 1995) or low (<20%; CCND1; Hovey et al (1998); and ERBB2; Bringuier et al (1996) frequency of altered expression or activity in tumours.
Thus, the following sections discuss the non-zero-offset extension of the two-step method, the approximations resulting from the application to vertically variable velocity fields, and finally the distortion effects on the aperture of the migration operators.
In this application to assist in the variables interpretation, continuous covariates "age" and "Simplified Acute Physiology Score" (SAPS) were respectively transformed as categorial variables by median or quartiles.
Continuous variables were expressed as the mean ± standard deviation, while frequency distributions were used in application to qualitative variables.
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