What's the damage?" Hynynen, who is working with a medical imaging company to commercialize the technique, notes that ultrasound application to the brains of animals including rabbits and monkeys has produced no negative side effects.
However, vector toxicity and transgene silencing have created significant barriers to vector applications to the brain.
This can be attributed not just to the growing use of genetically tractable model organisms, but also in large part to the rapid advances in optical techniques for neuroscience, which are ideally suited for application to the small, transparent brain of the larval fish.
In contrast, animal studies -- though limited in their application to the complex human brain -- can more definitively assess the relationship between drug exposure and various outcomes.
In this research, a novel implantable imaging system for fluorescence potentiometry was developed using a complementary metal-oxide semiconductor (CMOS) technology, and its application to the analysis of cultured brain slices and the brain of a living mouse is described.
A custom clamp was used to exert additional pressure on the cover glass after 2% agarose (type III-A; Sigma-Aldrich) or Kwik-Sil (World Precision Instruments) application to stabilize the brain during imaging.
A parametrization of the MolFESD is done for three solvents (n-octanol/water, alkane/water and cyclohexane/water) followed by its application to the prediction of brain-blood barrier partition coefficients (logBB).
The idea that game theory can find novel application to the internal dynamics of brains, as suggested in the previous section, has been developed from independent motivations by the new research program known as neuroeconomics (Montague and Berns 2002, Glimcher 2003, Ross 2005a, pp. 320 334, Camerer, Loewenstein and Prelec 2005).
The conference allowed a group of brain scientists to travel to one another's laboratories around the world, to compare notes on common problems, explore the possibility of joint projects, & identify new research techniques that could have early beneficial application to the diagnosis & treatment of brain disorders.
We also review the use of novel statistical approaches based on a network representation of the functional connectivity and their application to the study of the rat brain functional architecture.
