The persistent potentiation upon late application of NNC-711 and TBOA does also rule out that the block of potentiation by early application of uptake-inhibitors is caused by receptor desensitization through enhanced extracellular levels of GABA or glutamate.
In contrast to the application of uptake-blockers immediately after stimulation (Fig. 5E), delayed application of the drugs at 10 min after the stimulation did not reverse the initially established potentiation (23.4±1.5 pA versus 26.1±2.6 pA, with and without blockers, respectively; Fig. 5G).
After parenteral application, tissue uptake of doxorubicin is rapid, and elimination occurs mainly via biliary excretion after hepatic metabolism.
In this study, it was found that foliar application of ALA reduced the uptake of Pb in different parts of plants under Pb stress.
Making better use of autopsies in improving clinical practice among doctors practicing in resource-limited settings, with low rates of uptake and the application of advanced medical technology, is imperative.
Application of ultrasound increases the rate of uptake by this latter route, but does not appear to increase the uptake of drug into acidic vesicles, which still occurs at the normal rate.
As APP overexpression raises basal glucose uptake, and direct application of sAPPα increases PI3K protein kinase B signalling and glucose uptake in myotubes, we suggest that α-secretase-dependent shedding of sAPPα regulates insulin-independent glucose uptake in skeletal muscle.
Foliar application of glycinebetaine results in rapid uptake by leaves and concentration in meristematic tissues.
Application of N fertilizer increased N uptake, yield, and irrigation water use efficiency.
Malhi (2012) reported that the application of organic manures favored the uptake of N, K and S in wheat.
Following application of the KSF, background liver uptake was reduced and metastases were better visualised (Fig. 2a f).
