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Clinical considerations are also outlined and followed by two case examples that are provided to illustrate our application of the intervention.
It has been unclear whether the failure to translate promising results from animal studies in AKI into successful human trials has been caused by lack of therapeutic efficacy or inappropriately delayed application of the intervention.
Results were similar when stratified by the delay between symptom onset and application of the intervention (data not shown).
Secondly, our design results in an unavoidable delay between onset of symptoms in the index subject and the application of the intervention (Figure 2c).
The SARs were similar when stratified by the delay between onset of symptoms in the index case and application of the intervention (Table 2).
The standardized application of the intervention utilizes a conventional MP3 player and stereo headphones and therefore, requires no additional personnel.
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Results are reported in panels A, B of Figure 3, where application of the interventions is shown to reduce the probability values right after the peak of the distribution, with almost no change in the date of the peak.
The application of the interventions within the study relies on the skills of the treating physiotherapist.
This extensive information gives caregivers more insight in the practical application of the interventions in the study, which contributes to an easier implementation of the interventions in practice.
Although the application of the interventions did not fit into their current workflow (COM, paper: 2.57/IT: 3.50), physicians were willing to adapt their way of working (¬RTC, paper: 4.58/IT: 4.58/IT
Within these limits, other design considerations produced only modest differences in study population criteria between groups or differences in the application of the interventions, as highlighted below.
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