Sentence examples for application of targeting from inspiring English sources
In this study, besides tumor-infiltrating CCR6+ Treg-cells we have confirmed the direct contribution of CCR6 expressed by CMT93 CRC cells to the CRC growth and development in CCR6−/− mice, the clinical application of targeting the CCR6-CCL20 chemokine axis may harbor therapeutic potential for the treatment of patients with CRC.
The application of targeting a NR with specific ligands was further demonstrated by V Balasubramaniyan (Institute of Hepatology, University College London, London, UK).
Towards a clinical application of targeting the B7-H3 pathwey, wexamineded the therapeutic efficacy of anti-B7-H3-blocking mAb in pancreatic cancer.
The above data support a pivotal role for COX-2 expression in tumors treated with irradiation and thus justify studies to evaluate the clinical application of targeting COX-2 in patients undergoing radiation therapy as a treatment for prostate cancer.
These results also suggest the potential clinical application of targeting c-Src through pharmacological inhibitors in breast tumors expressing high levels of p130Cas and Cox-2, the same strategy already proposed in HER2-positive trastuzumab-resistant tumors to overcome trastuzumab resistance [ 44].
Therefore, EC0746 is a classic example of the application of targeted drug delivery, in this case the targeting of the antifolate (AMT) to FR-β-carrying cells.
They have served as nanocarriers in applications of targeting drug delivery systems.
The article also outlines a few examples predicting other possible applications of targeting such specific probes not yet used.
In addition to the obvious applications of targeting molecular signatures of vascular diseases (e.g., atherosclerosis), deep-tissue diseases often manifest themselves by continuously altering and remodeling their neighboring blood vessels (e.g., cancer).
In this minireview, we focus on recent findings of potential therapeutic applications of targeting the Syk-Btk axis in experimental glomerulonephritis models (Tables 1 and 2).
The successful applications of targeted proteomic methods such as SRM and SWATH MS require the one time generation of mass spectrometric reference maps for each component of whole canonical proteomes or specific subsets of proteomes (subproteomes), for example, those of particular clinical interest.
