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Badger, J., Wass, C., Weissman, S. & Kim, K. S. Application of signature-tagged mutagenesis for identification of Escherichia coli K1 genes that contribute to invasion of human brain microvascular endothelial cells.
Upon application of signature-tagged transposon mutagenesis, a homologue of agrA encoding a response regulator involved in Staphylococcus aureus virulence [ 33], has recently been identified as virulence factor of L. monocytogenes, because its mutation resulted in a ten-fold increase in the 50% lethal dosis [ 34].
Previous works on application of the signature descriptor have been limited to use with topological indices.
He attached himself to a powerful ideological élite, strengthening its cultural hegemony by his own skillful application of its signature jargon, stigmatizing those outside the cult by insisting on an exaggerated purity of approach, and thus securing the allegiance of the other members of the privileged coterie and distracting attention from his own corruption.
Noting Spector's application of his signature Wall of Sound production on "Awaiting on You All", Inglis writes that, but for Harrison's lyrics, the song "could be mistaken for the instrumental track of a song by the Ronettes", one of Spector's girl-group protégés during the 1960s.
The inverse correlation between MITF and HIF1a was also observed upon application of our signature to independent tumour data suggesting it is a biologically relevant in vivo.
Application of E2F4 signature to predicting prognosis of ER+ node-breast cancer.
The application of this signature to four different published sets of breast cancer was highly predictive of outcome [ 17].
In this study, we examined the application of sequence signature methods for the comparison of microbial metagenomic samples with NGS read data.
Based on a machine-learning model built from the application of this signature on a training dataset, a ΔΔ G estimate can be generated.
Future studies will focus on the application of this signature to other therapeutic modalities of interest, and on further understanding the contribution of key nodes or targets present within the signature itself.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com