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The application of mouse model may be useful in providing some elementary building blocks of consciousness.
With regard to the application of mouse WT-/FXRKO-PCLS to study FXR signaling in the liver, this model seems to have some limitations.
The first application of mouse transgenesis was a physiological one: the introduction of human growth hormone resulted in increased size (Palmiter et al., 1982).
The main goal of the present study was to assess whether application of mouse PCLS in combination with whole genome gene expression profiling is an useful approach to identify mechanisms leading to cholestasis.
In the proceeding section of this review we will discuss the application of mouse models for cancer gene discovery, including how insertional mutagenesis has been deployed to find cancer genes.
Kjaerulff and Kiehn applied circular statistics to measure the strength of right and left motor burst phase relationships and by precisely lesioning the spinal cord, they located the rhythmic centers producing the coordinated locomotor output. 1 The application of mouse genetics to manipulate classes of spinal neurons involved in establishing locomotor circuitry has been similarly useful (Fig. 1).
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This editorial is an overview of the development and applications of mouse models of cancer and directs the reader to upcoming papers describing the use of these models to be published in coming issues, beginning with three articles in the current issue.
However, development of cerebellum is normal in Syne1 −/− mice, which prevents the application of this mouse model to the study of this human disease.
Application of the mouse SB-induced mutagenesis strategy [10], [11] would provide a new method to genetically screen for novel cancer genes in zebrafish.
The most recent application of HIS mouse models has been extensive efficacy studies of cART therapies.
Thus, an application of anti-mouse CD24 mAb in a mouse syngeneic tumour model of gastric cancer led to a lethal toxicity due to a severe anaemia (data not shown).
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