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The significant number of potential lead sequences allowed for the application of more stringent lead criteria such as good solubility, high peptide sample purity and low background binding to the SPR chip surface.
This finding, which was unique to gC, also survived the FDR multiple-testing correction at the more conservative 0.05 threshold and the application of more stringent replication criteria for the construction of gene lists.
Application of more stringent cut-off levels revealed an average consistency of 368 (75%) and 153 (72%) differentially expressed genes between one and two rounds of amplification at a cut-off level of 3×SD (p < 0.003) and 4×SD (p < 0.0001) respectively.
Given the intensity of the intervention and facilitated pathways to higher doses of combination antihypertensive treatment, these data highlight critical questions around the application of more stringent blood pressure targets in high risk people that is, those with established cardiovascular disease or renal disease.
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12 Few studies, however, have specifically tested the application of structured care in the setting of more stringent, risk based blood pressure targets in a large and diverse range of general practices that is, small to large clinics and those with and without practice nurses to implement structured care.
As a result of more stringent conditions since the housing bust, bankers are required to be more diligent in approving loan applications.
Scholars attribute the decline in applications to several factors, including a wider availability of low-end jobs, new supports like the earned-income tax credit and a deterrent effect of more stringent welfare rules.
In Chile, stability effects are limited by means of more stringent drift limits.
Now there's talk of more stringent guidelines.
New York state exemplifies the benefits of more stringent laws.
241, 522 P.2d 1049, this court specifically addressed the question whether the provisions of title III of the federal Omnibus Crime Control and Safe Streets Act of 1968 (18 U.S.C. §§ 2510-2520, hereaftitleIIIe III) — relating to the wiretapping or recording of telephone conversations — preempted the application of the more stringent provisions embodied in California's invasion of privacy law.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com