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The finding that application of METH after pre-application of SCH23390 did not increase in baseline synaptic transmission further may suggest that the METH-mediated modulation of fEPSPs might in part be due to the release of endogenous dopamine and subsequent activation of D1/D5-like receptors (also see figure S1).
Both the acute ex vivo application of METH to hippocampal slices and systemic administration of METH decreased LTP.
First, acute ex vivo application of METH to hippocampal slices increases baseline synaptic transmission, independent of NMDA receptor activation.
We discovered that acute ex vivo application of METH increased baseline excitatory synaptic transmission and decreased LTP at CA1 synapses.
Interestingly, the acute ex vivo application of METH at a concentration of 30 or 60 µM increased baseline synaptic transmission as well as decreased LTP.
Since METH profoundly increases the concentration of extracellular dopamine, it is feasible that application of METH may have induced dopamine release to mediate a dopamine-receptor dependent increase in baseline synaptic transmission.
Similar(54)
As shown in Fig. 1E, the magnitude of baseline synaptic responses in the apical dendritic area of the CA1, measured as changes to the fEPSP slope, increased during a 30 min application of 30 µM METH.
Varenicline did not alter self-administration of meth or saline.
About 4lb of meth can be formed from each gallon of liquid meth, he said.
Suspect attempted to smuggle 4 pounds of meth.
Suspect attempted to smuggle 210 pounds of meth.
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