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Spasmolytic activity was observed by application of dose of extarct in cumulative fashion.
A widely used application of dose addition is the "toxicity equivalence factor" (TEF) concept for the assessment of mixtures of PCDD/Fs (van den Berg et al. 1998).
In this review, the critical role of imaging in radiation therapy is reviewed for the application of dose calculation, lesion location, and delineation.
It has been suggested that only major changes in the application of dose can be reasonably expected to have a discernible clinical effect [ 28].
Recently, the U.S. EPA conducted an evaluation of the application of dose addition for noncarcinogens and response addition for carcinogens, using the Comprehensive Environmental Response, Compensation, and Liability Information System database (U.S. EPA 2004a).
A widely used application of dose addition is the TEF/TEQ concept for the assessment of mixtures of PCDDs and PCDFs (Safe 1998; van den Berg et al. 1998).
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Mathematical models of tumor growth have provided the basis for the clinical application of dose-dense chemotherapy.
However, there is still evidence of their presence in various vegetables as a result of application of doses above the recommended dosage.
The observed response of the test material was quantified by the application of doses in a cumulative fashion.
Using linear regression analysis, XR11576 oral clearance was not significantly related to patient body surface area, confirming that the application of dosing per body surface area would not have optimised dosing of this agent.
Overall, controlling drug activity with light offers the possibility of enhancing pharmacological selectivity with spatiotemporal patterns of illumination, thus enabling localized drug effects and the application of dosing patterns.
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