It is envisioned that this system will ultimately find utility in drug delivery systems that are designed to release chemotherapeutic agents and peptides by the application of a triggering signal.
A cleavable linker that can replace an amino acid residue in the backbone of a (poly)peptide or protein will allow cleavage of the backbone into at least two fragments upon application of a defined trigger, but will require accessibility of the cleavage site to the trigger.
Following tensile and shear deformation to lock-in plastic strain, the SMP exhibited a rapid rise in the recovery force following the application of a thermal trigger.
In this article, a methodology is described to calculate the Rate of Return (RoR) on investing in fasteners which can be simultaneously released by the application of an external trigger, following the principle of active disassembly.
A hydrogel particle is a cross linked particle of sub-micrometer size composed of hydrophilic polymers capable of swelling and contracting as a result of the application of an environmental trigger, e.g., temperature, pH, ionic strength or electric field [10] [14].
Prospective application of an augmented trigger tool identified a wide range of factors contributing to AEs.
As a result, the application of Glu triggered a [Ca2+]i increase in HEK cells expressing OsGLR2.1 (Additional file 9), and pretreatment of La3+, a Ca2+ channel blocker, inhibited the [Ca2+]i increase.
(TIF 1119 kb) Additional file 9: The application of Glu triggered a [Ca2+]i increase in HEK cells expressing OsGLR2.1 (movie in the ppt file).
In Arabidopsis seedlings, the application of H2O2 triggers a biphasic Ca2+ elevation, with the first peak located in cotyledons and the second in the root (Rentel and Knight 2004).
