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The aim of research on infectious diseases is their prevention, and brucellosis and salmonellosis as such are classic examples of worldwide zoonoses for application of a systems biology approach for enhanced rational vaccine development.
Finally, it seems that the application of a systems biology approach for creation of an interactome map of maternal communication with gametes and embryos is essential and provides an excellent opportunity for an inter-disciplinary collaboration with engineers and mathematical modellers.
The wide scope of analysis as a weakness – because it makes the analysis more complex (which has been addressed through the application of a systems thinking approach) and because it becomes more difficult to consider every detail of the available information on the multiple factors considered.
Application of a systems biology approach uncovered a shift in energy metabolism by rosiglitazone that may impact cardiac pathological hypertrophy.
Application of a systems pharmacology-based approach enabled us to predict unknown biomarker profiles such as kidney PHD2 concentration levels and erythropoetic responses under various dosing scenarios.
Here, application of a systems biology-derived algorithm of bioinformatic dissection identified discrete gene ontology remodeling effects ascribed to either chaperone or calcium binding regions of CALR.
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The possibility of the application of a system of transient-state methods, based on numerical experiments (computer simulation of real experimental situations) in the case of transport with first- and second-order chemical reactions has been shown.
To elucidate our results, we present two examples together with an application of a system of integral equations.
One concern with the application of a system of linear equations such as used here is the mathematical structure of the problem: is it well posed, what is the dimensionality and conditioning of the matrix.
These criteria should be formalized through a consensus process or a governmental initiative that includes discussion and pilot application of a system for reproducibly implementing them.
In addition, guidelines could include the provision of translations for English versions, training and supervision in the management of costs and expenditure records in health facilities, and the application of a system of sanctions to ensure health workers adhere to charter details.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com