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Similarly, PNSA was less and SNSA was greater when snoring was abolished (i.e. non-snoring periods during trial 1 or during nCPAP application in trial 2) compared to when it was present (trial 1) within the snoring population.
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These studies demonstrate deficiencies in training and test application in trials.
The IPAQ was developed for application in trials comparing ease of use and preference between these specific injection pens with regard to injection pen attributes.
However, high cytotoxicity and low transfection efficiency substantially restrict their application in clinical trials.
The Preoperative Endocrine Prognostic Index (PEPI) that combines residual Ki67 score with measures of on-treatment ER and other clinicopathologic factors has also found application in clinical trials.
However it is uncertain whether the scale has sufficient sensitivity for application in clinical trials or whether the additional items are beneficial.
This study identified the use of a management protocol for early identification and uniform treatment of patients with massive bleeding for application in future trials of hemostatic rescue agents.
Five months after its application in field trials, we took soil samples for reisolating FZB42 derivatives.
VLX600 is a novel compound targeting OXPHOS that inhibits tumor growth of colon carcinoma cells, thus exhibiting potential application in clinical trials [231].
To better understand the exact mechanism of the effects of B.vulgaris and to develop its application in clinical trials, additional genes involved in glucose and lipid metabolism and related signaling pathways should be investigated.
However, the increased toxicity, which is the price to pay for the synergism, becomes the main shortcoming of the strategy and is the limiting factor in its application in clinical trials.
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