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Unfortunately, despite its increased application in this setting, improved outcomes have been hard to come by.
Although a moderate correlation was noted between CLCR and CG (rs = 0.26, P = 0.017) and 4-variable MDRD (rs = 0.22, P = 0.047), neither had acceptable precision for clinical application in this setting.
Although various mathematical estimates of glomerular filtration are widely applied [ 19, 20], each was primarily designed for use outside of the ICU, making application in this setting flawed [ 21, 22] and of little value in guiding therapy.
Methods to derive tests and confidence intervals, fit statistics and (best-linear unbiased) predictions have been previously developed within the linear mixed models framework for the application in this setting, together with a description of the software implementation in the R package mvmeta[ 12].
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This investigation studied their application in the setting of acute myocardial ischemia and reperfusion (I/R).
Therefore, it may have further application in the setting of experimental protocols for designing control methods.
More recently, its application in the setting of major trauma has been described [ 3].
It should be noted that a recent meta-analysis suggested that safety aspects of heparin in sepsis are underreported, and we conclude that risk of bleeding is a potential concern for the application of heparin in this setting [41].
Some of the major pitfalls of mandated IAV vaccination lie with the practical application of vaccines in this setting.
In 2001, a report of two cardiac surgery cases in which bleeding was controlled using a PCC demonstrated the potential application of PCC in this setting [ 17].
The next stage for the application of WINGS in this setting is extension to other clinical omics use cases, as well as clinical user evaluation to facilitate seamless integration in these settings.
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