Imaging can also provide outcome measures, such as change in tophus volume, for monitoring the response to urate-lowering therapy and this is an important application in the clinical trial setting.
For each application, data were extracted on trial characteristics, references to PPI in the development of the outline application and funding Board feedback, and plans for PPI in the full application and after the trial was funded.
Last December the FDA refused to consider ImClone's application, citing flaws in the trial.
Here, Article 201, is further defined through the "Interpretation of the Supreme People's Court on Some Issues concerning the Specific Application of Laws in the Trial of Criminal Cases for Tax Evasion and Refusal to Pay Tax" ("SPC Interpretation").
Table 5 Comparisons between treatments for stand volume (m3 ha−1), recorded 2.5 years after treatment application in the Pinus radiata trial Treatment comparisons Difference in stand volume P value Result CTH-Oct vs CTH-Oct x2 (treatment 7 vs treatment 6) −2.40 0.001 Significantly lower volume where weed control was carried out in October of year 1 compared with control over both years.
The European court of human rights refused an application concerning the trial in 2007.
Photobiomodulation for stimulation of mandibular condylar growth may be close to application in the clinic because clinical trials using LED in patients undergoing orthodontic treatment have identified enhanced tooth movement and minimal side effects, such as root resorption.
Very low intra-observer variability is reported for this methodology, but inter-rater variation, a crucial issue if wider, reliable application in the context of clinical trials is to be useful, remains to be tested.
Similarly, PNSA was less and SNSA was greater when snoring was abolished (i.e. non-snoring periods during trial 1 or during nCPAP application in trial 2) compared to when it was present (trial 1) within the snoring population.
They thank Prof Peter Croft who led the NIHR Applied Programme Grant application in which the BEEP trial is funded and Prof Michael Doherty who helped with the initial trial idea development.
Thus, unlike the clinical setting, where opportunities for hand disinfection are present over the whole shift, and the hands have the chance to dry in between applications, in our trial the test preparations accumulated on the skin.
