These findings have applications in elucidating the causes of an HCV infection outcome, as well as providing evolutionary insights as to the selective forces behind specific infection outcomes.
20, 22, 46 We anticipate that multicolor super-resolution imaging with this approach could find applications in elucidating the composition and organization of multi-component protein complexes, for example.
In this review we survey the application of SRM in elucidating the structure of macromolecules in the native cellular environment.
Another case study involving blood or blood-substitute preparations demonstrates the application of animal studies in elucidating underlying physiologic mechanisms of clinical relevance.
The latter application has proven valuable in elucidating areas as diverse as the effects of copper in the soil on earthworms [ 69] and the mechanism of testicular toxicity induced by the industrial solvent ethylene glycol monomethyl ether [ 70].
The ability to rapidly and accurately predict the effects of mutations on the physicochemical properties of proteins holds tremendous importance in the rational design of modified proteins for various types of industrial, environmental or pharmaceutical applications, as well as in elucidating the genetic background of complex diseases.
The applications of systems biology in elucidating human disease are highlighted, consisting of human disease networks, treatment response prediction, investigation of disease mechanisms, and disease-associated gene prediction.
Our results demonstrate the unique application of ψ-value analysis in elucidating the structure of the transition state that occurs during the mechanical unfolding process, offering a potentially powerful new method for investigating the design of novel elastomeric proteins.
Such kind of direct somatic embryogenic system without exogenous application of plant hormones is invaluable in elucidating early regulatory events in embryo development [ 44].
In doing so, they suggested that the application of a multidisciplinary approach increased their confidence in elucidating the source of the incursion.
