Exact(1)
Keyhani et al 13 considered the time taken from the Investigational New Drug (IND) Application (a step required by the US Food and Drug Administration FDAA) prior to testing in humans 14) to the filing of a New Drug Application 15 and subsequent FDA approval (the latter time points representing the regulatory review process).
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In this article, we highlight state-of-the-art virus engineering principles and discuss recent advances that bring potential biomedical applications a step closer.
Such approaches rely on the change in some measurable property, most commonly conductivity, upon application of a step change in gas-phase oxygen partial pressure.
The application of a step force stimulus illustrates the high sensitivity of the hair cell model to static stimuli in the regime of irregular oscillations (Figure 11a).
The PINV application is a step further than the examples described in the manuscript, that possibly deserves a bit more description in the text and could guide the reader on how to build up from simple cases to more complex applications.
In some applications a step-up transformer is placed between a LV drive and a MV motor load.
So the judge suspended Mr. Mohansingh's deportation proceedings until the I.N.S. acted on his "alien relative" visa application, a preliminary step toward his winning a green card that would prevent his expulsion.
After DAP application, a further step consisting in a limewater-saturated poultice, aimed at overcoming possible issues connected to the presence of unreacted DAP in the treated stone, was performed and an "application cycle" was finally proposed.
Thus, in view of a large scale application, a two step depuration process would be required, where the photobioreactor will remove nutrients as N and P and an activated sludge reactor downstream will reduce the organic matter.
This is the reason why the 3D probability tomography approach has not required in this application a further step, aimed at associating true resistivity values to the revealed anomaly sources.
Utility based resource allocation methods generally model the utility of inelastic applications as a step function of rate, which reflects the requirement to achieve a constant bit rate if this user is active.
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