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When experimental measurements are not available, using the same value of plasma volume normalized R0 may be applicable to cell surface targets that are widely expressed throughout the body or circulating soluble targets in the central compartment for adults and pediatrics.
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Our findings yield a new design concept of cell repelling and trapping surfaces which are applicable to cell guiding methods and single or multiple cell confinement on cell culture substrates, and thus may contribute to development of more advanced biomaterials.
Therefore, the wettability assessment method applicable to cell culture dish systems is in high demand.
Much of our research involves cell surface oligosaccharides, biopolymers that contribute to cell surface recognition and cell-cell communication.
This method is widely applicable to cells that have sialic acid on the surface.
This is significant, since it implies that cell shape/cell function relationships that are deduced from using engineered 2-D surfaces might not readily be applicable to cells in 3-D environments.
Epithelial cells use two pathways to send proteins to the cell surface.
However, it is clear from the example of TbHpHbR that this mode of ligand binding is potentially applicable to other GPI-anchored cell surface proteins.
Flow cytometry was used to identify cell surface antigen.
One limitation of this study however is that it is currently unknown whether the results are applicable to other titanium surfaces with differing surface topographies or surface modifications.
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