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This digest paper provides an overview of recent development in prodrug strategies for drugs with a carboxylic acid or hydroxyl/amino group on the basis of a generally applicable modification strategy, such as esterification, amidation, or benzylation.
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The results show that easily applicable modifications of window constructions could improve their thermal performance.
These prodrugs can be easily designed and synthesized because of their generally applicable modifications.
Readily applicable modifications to RNA can range from isotopic labels and fluorescent or other molecular probes to protein, lipid, glycoside or nucleic acid conjugates that can be introduced using combinations of synthetic chemistry, enzymatic incorporation and various conjugation chemistries.
To perform this analysis, we adopt an iterative analysis approach in which we model and simulate the mission architecture, assess its feasibility, implement any applicable modifications while attempting to remain within the constraints set forth by Mars One, and then resimulate and reanalyze the revised version of the mission architecture.
Quantification of intestinal bacterial density was adapted from previously described methods with applicable modifications (Oehlers et al., 2011b).
Do the laws of quantum physics remain applicable without modification even up to the macroscopic level?
The proof will carry over; the ε−δ description of continuous mappings is still applicable without modification.
Here we introduce the Generalized Long Short-Term Memory(LSTM-g) training algorithm, which provides LSTM-like locality while being applicable without modification to a much wider range of second-order network architectures.
On the other hand, the information of fuzzy cognitive map modelling is applicable for modification of neural networks structure for providing more accurate results based on the extracted knowledge from the cognitive map and visualization of the system's performance.
The strategies reviewed in this article are applicable to modification of DNA molecules of any size, including very large ones, and present powerful new avenues for DNA manipulation in general.
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