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The TNF-related apoptosis-inducing ligand (TRAIL; Apo2L/Dulanermin) as well as TRAIL-agonistic antibodies are able to kill a broad range of tumor cell lines in vitro, are well tolerated in vivo and thus applicable for therapy of cancer.
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The results of this study suggest that locally delivered tyrphostin AGL-2043 formulated in biodegradable NP may be applicable for antirestenotic therapy independent of stent design or type of injury.
Thus, modified CT response evaluation criteria could be applicable for imatinib therapy [ 3, 53].
Due to its high toxicity as free drug and low activity at tolerated levels, Maytansine requires a specific targeting to become applicable for antitumor therapy.
Our current results showed that the PSA -and MMP2-based prodrugs are applicable for the therapy of PSA-positive and PSA-negative PrCa, respectively.
Consequently, it is necessary to develop new vaccination protocols to induce strong anti-tumor immune responses that are applicable for the therapy of the pancreatic cancer.
The drug release is enhanced at pH 5.0 which is applicable for cancer therapy due to the low pH environment in tumors and within endosomes after internalization by cancer cells.
Although current advances in genetic targeting of specific cell populations have greatly contributed to the identification of genes, cells and mechanisms involved in liver fibrogenesis, these strategies are barely applicable for human therapy, but they do help to define suitable therapeutic targets.
A safer method, without genome integration, is therefore required for the delivery of reprogramming factors to somatic cells to generate iPSCs applicable for transplantation therapies.
The former two ceramic scaffolds proved to be applicable for bone regeneration therapy.
This highly efficient gene transfer to exocrine acinar cells might be applicable for the gene therapy of pancreatitis, pancreatic malignancy and exocrine enzyme insufficiency, for example.
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