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In this article, the authors review key points that practitioners should consider when assessing randomized controlled clinical trials so they can determine the applicability of study results to clinical practice.
It also limits the applicability of study findings to patients in other clinical settings.
The selection of subjects for clinical trials, in particular, raises questions with regard to the applicability of study findings to the broader food-allergic population.
As such, it does not lead to biased estimates of reliability, but it can limit the applicability of study results [ 94].
Enrolling older adults who have multiple co-morbidities such as obesity, diabetes, high blood pressure and arthritis of other joints will improve applicability of study results.
These are key to understanding the transferability and applicability of study results and the potential for study bias (Hayden et al, 2006).
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Regarding applicability of studies to the review questions, there were no concerns about the index test or reference standard.
The applicability of studying autophagy in the tail fin infection model was demonstrated using M. marinum infection.
The quality and applicability of studies were assessed before their findings were examined (Glasziou et al, 2001) (Appendix B, strategy for selection of eligible studies).
Indeed, a recent Cochrane Review[ 7] of this topic could draw no conclusions due to the very small number and low quality, or limited applicability, of studies.
Regarding the applicability of studies to the review questions, no study raised concern about the index test, reference standard or patient selection.> -wrap-foot> Risk of bias and applicability concerns summary based on the QUADAS-2 checklist.
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