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Regarding applicability of studies to the review questions, there were no concerns about the index test or reference standard.
The quality and applicability of studies were assessed before their findings were examined (Glasziou et al, 2001) (Appendix B, strategy for selection of eligible studies).
Indeed, a recent Cochrane Review[ 7] of this topic could draw no conclusions due to the very small number and low quality, or limited applicability, of studies.
Regarding the applicability of studies to the review questions, no study raised concern about the index test, reference standard or patient selection.> -wrap-foot> Risk of bias and applicability concerns summary based on the QUADAS-2 checklist.
Systematic reviews in breast cancer (Altman, 2007), neuroblastoma (Riley et al, 2003), prostate cancer (Sutcliffe et al, 2009) and bladder cancer (Malats et al, 2005) found that poor reporting was common and limited the clinical applicability of studies.
Studies were systematically assessed for quality based on the validated Quality Assessment of Diagnostic Accuracy Studies (QUADAS -2 checklist [ 5], which assesses the risk of bias and clinical applicability of studies based on four key domains: patient selection, index test, reference standard, and flow and timing.
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In this article, the authors review key points that practitioners should consider when assessing randomized controlled clinical trials so they can determine the applicability of study results to clinical practice.
It also limits the applicability of study findings to patients in other clinical settings.
The applicability of studying autophagy in the tail fin infection model was demonstrated using M. marinum infection.
These are key to understanding the transferability and applicability of study results and the potential for study bias (Hayden et al, 2006).
The selection of subjects for clinical trials, in particular, raises questions with regard to the applicability of study findings to the broader food-allergic population.
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