As a final test of the overall broad applicability of the contrast agent, we performed imaging studies in a lung adenocarcinoma mouse model in the KrasLSL-G12D/+; p53 flox /flox; R26LSL-tdTomato/+ (KPT) mouse model of adenocarcinoma in which lung tumors are induced in mice by intratracheal infection with lentiviral delivering Cre recombinase.
This may limit the scope of applicability of this type of contrast agent, depending on the characteristics of the therapeutic target tissue, and requires a careful investigation of the signal decay source with respect to the chosen TE for the experiments.
We have shown the applicability of an optical phase contrast detection (OPCD) method in PAT [ 16].
The applicability of these liposomal MRI contrast agents was, however, limited because entrapment of the Gd and Mn effectively leads to very low relaxivity the parameter that defines the potency of the agent to introduce contrast in the MR images due to limited water exchange across the liposomal bilayer.
The simple applicability of the inferred formulae contrasts with the classical and huge time consuming numerical approaches, these formulae being suitable tools in the design process of the structure operating in the micro-world.
This heterogeneity necessarily requires a narrative synthesis and prevents meta-analysis, and may limit the applicability of some results to contrasting ambulance systems.
We investigated the applicability of the albumin-binding MR contrast agent, gadofosveset, to noninvasively monitor focal changes in vascular permeability and remodeling, after injury, in NOS3-knockout (NOS3−/−) and wild-type (WT) mice in vivo.
In this study, we investigated the applicability of the albumin-binding MR contrast agent, gadofosveset, to noninvasively monitor focal changes in vascular permeability and remodeling, after injury, in NOS3-knockout (NOS3−/−) and WT mice in vivo.
ATLAS has potential applicability to a range of contrasting agricultural landscapes.
High relaxivity along with low cytotoxicity of PSS-stabilized colloids indicates their applicability as contrast agents in MRI.
