appropriate measures of goodness-of-fit, robustness and predictivity; 5. a mechanistic interpretation, if possible.' . a defined endpoint; an unambiguous algorithm; a defined domain of applicability; appropriate measures of goodness-of-fit, robustness and predictivity; a mechanistic interpretation, if possible.'.
A (Q SAR model for regulatory purposes should be associated with the following information: 1) a defined endpoint 2) an unambiguous algorithm 3) a defined domain of applicability 4) appropriate measures of goodness-of-fit, robustness and predictivity 5) a mechanistic interpretation, if possible. . a defined endpoint.
In 2004, following five OECD principles for model validation were adopted to validate a QSAR model for its regulatory consideration: a) a defined endpoint; b) an unambiguous algorithm; c) a defined domain of applicability d) appropriate measures for goodness-of-fit, robustness and predictivity and e) mechanistic interpretation, if possible [3].
Extensive computational experiments on three different kinds of toothbrush handles are performed and the results demonstrate the applicability and appropriate performance of algorithms.
All evaluations complied with the following quality criteria: presence of a clear hypothesis, methodology, selection of comparators, choice of appropriate benefits, and local applicability.
Toning down the immediate applicability of your findings might be appropriate.
The application of an appropriate gate voltage, like 0.6 V for example, presents a clear difference of modulation for each concentration of KCl, which demonstrates the sensing applicability for the device.
Second, this technique has broad potential applicability across species, limited only by the availability of appropriate antibodies that can be conjugated to saporin, creating an melanopsin cell-specific immunotoxin.
To improve the ease of applicability, we describe their ecological interpretation and advocate the use of appropriate analyses (i.e. null models and/or rarefaction) to disentangle different drivers of the pattern and control for sampling effects.
The validity of data used in the decision-making process depends on the measurement technique used to obtain the data and the appropriate scale of applicability of the technique.
