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This implies the robustness of the linear-quadratic (LQ) formalism in predicting dose response and its clinical applicability in the setting of lung SBRT.
The HIVE mouse model has proven to be useful for efficacy studies to screen potential neuroprotective compounds, such as sodium valproate (Dou et al., 2003), for their applicability in the setting of HIV-associated neuroinflammation.
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The safety, low-cost, and functionality of this protocol broadens its applicability in the clinical setting.
However, its utility and applicability in the ICU setting remains unexplored.
Our findings showed that present dosing recommendations are based on studies with drawbacks limiting their applicability in the clinical setting.
Clinical practice guidelines are by their nature general recommendations aimed for broad applicability in the clinical setting.
The relative ease of preparation, applicability in the clinical setting, favorable safety profile and possible beneficial outcome make PRP a promising therapeutic approach for future regenerative treatments.
The results of this study confirm the feasibility to evaluate LV dyssynchrony with phase analysis by GMPS and its applicability in the clinical setting.
With the development of therapeutic approaches with the potential to activate NKT cells in vivo (Nieda et al, 2003) and expand NKT cells in vitro (Nieda et al, 1999; Nicol et al, 2000a; Takahashi et al, 2000), it is important to more clearly define their applicability in the clinical setting.
Second, because our study excluded patients with cardiac arrhythmias, we do not know its applicability in this setting.
However, the applicability of THx in the setting of high brain compliance has not been addressed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com