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A shortcoming of current enzymatic and chemical methods for genome editing is their limited applicability for in vivo studies.
Although DZX is a useful tool for in vitro mitoKATP studies, this drug has limited applicability for in vivo myocardial protection, since its effect on pancreatic islet K+ channel transport results in decreases in insulin secretion [46].
We demonstrated the method's improved accuracy on simulated data and its practical applicability for in vivo imaging of embryonic rats.
This is expected to improve the predictive and explicative capabilities of kinetic models, and thereby their applicability for in silico design of industrially competitive cell factories [ 46].
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They also reported on in-wood non-destructive measurements to determine applicability for in-forest sorting of veneer quality logs in second growth Douglas-fir and found it likely to improve recovery of higher quality logs (Amishev and Murphy 2008b).
Obtaining good preclinical data is the foundation of all clinical trials and the data must be considered in light of its applicability for use in humans.
The inferior performance of both military scores when applied to our dataset calls into question their applicability for use in the civilian trauma setting, in which the majority of patients suffer blunt trauma.
The results show the performance of the model and its applicability for use in the planning of recovery operations in the automotive industry.
We present an efficient and cost-effective method for genetic mapping using natural variation segregating in defined recent Anopheles founder colonies, and demonstrate its applicability for mapping in a complex non-model genome.
Moreover, the paper presents a novel technique to move between the PI and PID configurations of the controller such that the minimum overshoot and ripple are obtained, which increases the controller applicability for utilization in PV systems supplying sensitive loads.
Triggering this system by use of air pressure may restrict its applicability for use in vacuum.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com