However, these markers remain unsatisfactory because of their low sensitivity and/or specificity or because of their limited applicability, for example, telomerase in breast lesions (Clark et al, 1997) or ret/PTC rearrangements in thyroid cancer (Cheung et al, 2001).
The increasing number of successful trials has driven the development of gene therapy approaches to include more widespread applicability, for example, in cancer and chronic or progressive diseases such as heart failure, neurodegenerative or metabolic disorders, including Parkinson's and diabetes (Elsner et al, 2012; Jessup et al, 2011; LeWitt et al, 2011).
It should also be noted that while meanings that derive from gay communities may have certain international applicability (for example, between the US, Western Europe, Australia, New Zealand, and the United Kingdom), MSM globally are culturally diverse so assumptions should not be made that stigma will be experienced in the same way across different cultural settings.
learning curve effect and applicability difficulty, for example.
We show the compatibility of different concepts of in vitro synthesis toward biosensor applicability by the example of Cyt-bo3 protein expression.
It is well-known that analysis of incomplete Cholesky and LU decompositions with a general dropping is very difficult and of limited applicability, see, for example, the results on modified decompositions (Dupont et al., 1968; Gustafsson, 1978; Bern et al., 2006) and later results based on similar concepts.
ME are of interest due to their wide applicability [see for example Chen et al. (1999); Ng and McLachlan (2007) and, more recently, Gormley and Murphy (2008)] and the advantages of fast learning via the expectation maximization (EM) algorithm (Dempster et al., 1977; Jordan and Xu, 1995).
Sample 2D numerical examples demonstrate applicability of the model as well as efficiency of the SGBEM and convex programming numerical implementations.
The model applicability is corroborated by an example, based on a published case-study.
In this paper, we have presented a new algorithm for constructing a consensus MUL-tree(s) from a collection of MUL-trees, and illustrated its applicability using two examples.
