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However, its applicability, i.e., its ability to be applied on vertical surfaces and even on ceilings was not endangered at any time.
Most importantly, we need to consider how OECD Test Guideline No. 222 must be modified to ensure its general applicability (i.e., whether certain soil types should be excluded).
In addition, as a nuclear gene, the nu ITS2 rRNA gene is likely to have broader taxonomic applicability (i.e., beyond Viridiplantae) should it be deemed a good DNA barcode.
Some articles referred to the notion of "pure" transferability (outcomes-focused) or did not discriminate between the concepts of transferability and applicability (i.e., the extent to which an intervention process could be implemented in another setting [ 3]).
The abstract of that study [ 27] claims that the usability of i2b2 was evaluated, but it actually rather evaluated the applicability (i.e., if it can be used for a given scenario) than the usability.
The top 10 of exon skips and their added applicability (i.e., taking this adjustment into account) is shown in Table 2. Substitutions involving a CpG dinucleotide accounted for 31% (233/756) of point mutations within the database.
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For test set samples, their known activities allow to classify them as either within or outside the model's applicability domain (i.e., either within or outside the "strip").
Because kNN models interpolate activities from the nearest neighbor compounds in the relevant training sets, a special applicability domain (i.e., similarity threshold) should be introduced to avoid classifying compounds that differ substantially from the training set molecules.
However, because all the models are developed in kNN QSAR modeling by interpolating activities of the nearest neighbor compounds only in the relevant training sets, a special applicability domain (i.e., similarity threshold) should be introduced to avoid making predictions for compounds that differ substantially from the training set molecules.
The aim of this study was to analytically validate the applicability of I-FISH in assessing 9p deletion in ccRCC and to clinically assess its long-term prognostic impact following surgical excision of ccRCC.
In addition, the lack of standardization of scoring with different cut-off thresholds used to determine 9p loss represents a major challenge to the applicability of I-FISH in a clinical setting [ 42].
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