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Because the secondary pore appears to close in a TEC with a closed trigger loop conformation and because trigger loop opening appears important for PPi release and translocation, if NTP-Mg2+ loading occurs prior to PPi release, it appears that this NTP must load through the main RNAP channel and not the secondary pore.
But it appears to close them — firmly — behind it as well.
O'Brien's announcement appears to close the door on any possibility of Frankie Dettori securing a Derby mount.
Hamilton, it turns out, has discovered hitherto unknown evidence that appears to close the book on the cause of McCandless's death.
And "Love Will Remember" appears to close the chapter on Ms. Gomez's relationship with Justin Bieber: "We lit the whole world up before we blew up/I still don't know just how we screwed it up".
While the new status of forces accord appears to close the door on any future American training, advisory or other military support after December 2011, this is contrary to a November 2007 joint declaration by Washington and Baghdad and is unlikely to be the final word.
Similar(48)
Mr. Alexander appeared to close the door on additional major amendments to the deal.
The strife broke out Saturday just hours after another sectarian saga had appeared to close.
He appeared to close his eyes during the hearing and awkwardly signed documents while handcuffed.
The verdict appeared to close a wrenching case that had exemplified troubled race relations in New York.
His pursuit of Stagg appeared to close his mind to the possibility of other suspects.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com