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The "sandwich" therapy for high risk EC appears to be tolerable and effective.
However, this spurious primer amplification appears to be tolerable, since tested genes were consistently detected by QPCR in all the Bst-amplified samples but not in the amplified negative control.
Together, our analyses suggest that multiple scattering contributes at maximum roughly 10% to the intensity value and that at least for structure determination at 2.9 Å resolution such an error in intensity appears to be tolerable.
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We found that with a fixed dose of cyclophosphamide of 500 mg m−2, a losoxantrone dose of 45 mg m−2 appeared to be tolerable.
There was a lower incidence of grade 3 mucositis after the dose was lowered; the side effects of the combination appeared to be tolerable at this dosing.
Median OR rate (ORR) was 58% in group A, including 1 CR, and 59% in group B. This combination appeared to be tolerable, with 16% (A) and 29% (B) AMG 386 discontinuations due to AEs [ 46].
In the current study, cabazitaxel given on a weekly schedule appeared to be tolerable with a manageable side-effect profile, despite the fact that cabazitaxel was administered without premedication.
The maximum tolerated dose was not formally reached at DL-V, but because of progressive anaemia and asthenia/fatigue, it was decided to test a new DL-VI with doses of paclitaxel 200 mg m−2, ifosfamide 5.0 g m−2and cisplatin 100 mg m−2; this appeared to be tolerable and is recommended for further phase II testing.
This is an interesting class of variant as, whereas some substitutions appear to be tolerable and the underlying variants are common polymorphisms, others have been implicated in a range of genetic diseases such as cystic fibrosis, muscular dystrophy and sickle cell anemia [ 3].
To conclude, the combined RCT regimen irinotecan plus 5-FU with radiation therapy appears to be a tolerable adjuvant therapy (Kalofonos et al, 2003) that results in a good tumour response when given pre-operatively to patients with rectal cancer in whom resection is either possible or uncertain (Mehta et al, 2003; Klautke et al, 2005).
Overall, NAC treatment appears to be safe and tolerable.
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