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Based on our RNAi experiments in adult flies, the presence of Blt in the ovaries appears to be functionally important and the loss-of-function phenotype in adult flies included both morphological and functional (e.g., oviposition) alterations and deficits.
In addition, Spt10 appears to be functionally related to Asf1, the Hir complex, and the Caf-1 complex, whose functions are connected in histone gene regulation, transcriptional silencing, and chromatin assembly (Amin et al. 2012; Eriksson et al. 2012; Kaufman et al. 1998; Sutton et al. 2001).
The articles in this series on Dialectical Behavior Therapy (DBT) have each identified a population of patients for whom emotion dysregulation appears to be functionally related to their presenting problems.
Analysis of reciprocal heterokaryons suggested that the cellular factor(s) required for efficient assembly and release of infectious virions is lacking in murine cells but appears to be functionally present in mink as well as human cells.
As such, feline lung contains significant amounts of UT mRNA and this receptor appears to be functionally coupled to bronchoconstriction (the peptidic tool compound GSK248451 representing a sub-nanomolar inhibitor of such effects).
Occasionally relaxation may appear to be complete.73, 74 However, in such instances careful inspection of the LES recording usually reveals subtle abnormalities such as a delayed onset and shortened duration of relaxation, and relaxation appears to be functionally inadequate.61, 75 Basal LES pressure may be increased in about 50% of patients.
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These biomarkers suggest that the alveolar barrier function appeared to be functionally restored on post-exposure day 7.
Thus, like the Hedgehog pathway in Drosophila, CDK9 (P-TEFb) and CDK11 appear to be functionally linked for Tat function.
In contrast to some of RPGRIP1 partners, the RPGRIP1-dependent subcellular processes appear to be functionally redundant for kidney function (Mollet et al., 2002; Otto et al., 2002; Wiik et al., 2008; Won et al., 2009; Won et al., 2011).
Moreover, the endogenous Totivirus-like genes appear to be functionally maintained with non-viral functions and may have been further transferred between deeper yeast lineages.
While most nsSNPs appear to be functionally neutral, the others affect protein function and may cause or influence diseases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com