Exact(5)
Protein structural features are likely to constrain insertions to specific parts of proteins, creating the appearance of recurrent indels.
We found a survival advantage for patients treated with the EPI-LV-5-FU regimen and a consistent delay in the appearance of recurrent or metastatic cancer.
In agreement with this hypothesis, reducing external Ca2+ from 2 to 1 mM resulted in a 100% appearance of recurrent or continuous seizure-like activity (Isaev et al., 2012).
The sensitive detection of arterial vascularity in metastases suggests the potential usefulness of CEUS in the therapeutic assessment of metastasis after local ablation, which is often difficult on dynamic CT or MRI due to the hypoattenuating or hypointense appearance of recurrent tumor similar to that of an ablated zone.
One suggested follow up scheme is to obtain imaging at regular intervals (i.e. CT or MRI every 3 4 months for 2 years, then every 4 6 months for 3 5 years, and every 12 months thereafter. Follow up for greater than 5 years is recommended as although most sarcomas (whether high-grade or low-grade) recur within 2 years, marked delay in appearance of recurrent disease is not unusual.
Similar(55)
A retrospective study in our own centre, evaluated MRI appearances of recurrent cervical cancer in 49 patients, of whom 70.4% recurred within 1 year following treatment.
The patient suffered from recurrent pneumonia for 6 years after the appearance of the recurrent hiatus hernia.
A substantial divergence in the landscape of driver alterations was associated with distant appearance of a recurrent tumor from the initial tumor, suggesting that the genomic profile of the initial tumor can mislead targeted therapies for the distally recurred tumor.
However, conventional MRI still has limitations when the morphological appearance of early recurrent or residual disease overlaps with normal pelvic anatomy or treatment effects in the pelvis.
For instance, a prominent periprostatic venous plexus may sometimes mimic the appearance of enhancing recurrent tumor on DCE images; therefore when there is this potential pitfall DWI is mandatory to exclude the presence of abnormal tissue in the post-prostatectomy bed.
The appearance of the recurrent HCCs suggests that they either developed as de novo malignancies from the liver allograft tissue itself, or from implantation and growth of circulating tumor-initiating cells derived from the patient's original tumor that persisted in the patient's lymphatic or vascular system following native total hepatectomy.
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