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Some remote regulatory elements appear to interact physically with target promoters in the 3D nuclear space.
Moreover, genes with conserved order were found to evolve at similar rates [ 4] and, in prokaryotes, proteins encoded by genes with conserved order appear to interact physically [ 1].
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For example, the OsSalT (Os01g24710, jacalin-like lectin domain protein) protein appeared to interact physically with four OsRFPs (OsRFPH2-3, OsRFPH2-16, OsRFPH2-23, and OsRFPH2-23).
Furthermore, the N1 residue appears to interact with N3.
It also appears to interact with Med10.
"They are asked to interact: physically, politically and emotionally.
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Then, we examined the ability of Tiam1 to interact physically with Rac1 in response to NGF.
Like Dre2 (Fig. 4), hCiapin1 is able to interact physically with yeast Tah18 (Fig. 5-G).
Dsh has been shown to interact physically with N and to inhibit its signaling during Drosophila wing bristle development [49].
PRDM16 has been shown to interact physically with SKI to inhibit transforming growth factor-β signaling.
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