Many potential interacting proteins for USP19 were identified, but none appeared to be putative ubiquitin protein ligases or known modulators of G1 to S progression.
37% of these predicted functional orthologs appeared to be "putative uncharacterized proteins" or "conserved Plasmodium proteins" of unknown function.
In contrast, some low-copy-number families (BmHel-2 and 5) appeared to be putative autonomous elements.
The other two proteins lacking predicted transmembrane domains (LmjF28.1480, LmjF32.2160), also appear to be lacking putative lipidation sites, so their membrane attachment may be mediated by binding to another SNARE, as suggested for human SNARE SNAP-25 [ 21].
There appear to be two more putative globins, CG15180 (209and and CG14675 (195aa); both provide acceptable alignments.
However, ACE was also expressed at a similar level in normal HMG, and therefore does not appear to be interesting as putative target gene for 17q23 amplification.
Conversely, two smaller S. Montevideo genomes, 162 and 205, appear to be missing the putative Salmonella phage sequence relative to the outbreak cluster (i.e., clade IV, Figure 1).
In PAa, CHPmethylase (PA0043 and paralogues) is the dominant methylase with 12 copies, although 7 copies of a putative methylase (PA0253 and paralogues) were detected, of which 5 appear to be fragments of the putative full-length protein.
Recently, the DNA replication licensing pathway has been proposed as a selective target for anti-cancer therapy, since tumour cells appear to be deficient in a putative licensing checkpoint.
Moreover, these defects appear to be independent of a putative Tyr phosphorylation, because another variant, in which the Y10 is replaced by a phenylalanine (foscrb Y10F), completely rescues the embryonic lethality of crb mutants (Klose et al., 2013).
