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The pathophysiology mechanism of migraine is quite complex, involving multiple neural pathways that appear to be pivotal during the process [111].
PPMTase and PMPMEase thus appear to be pivotal regulating polyisoprenylated protein function.
Multi-level selection and genomic conflicts appear to be pivotal in this process, but the details are hypothetical.
Neutralizing antibodies directed towards the E protein appear to be pivotal antibody that mediates homologous protection against reinfection.
Screening 527 deletion strains for ESRTs lead to the identification of 249 genes that appear to be pivotal for resistance to ER stress in the WT.
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Robson's inclusion appeared to be pivotal for United.
Consequently, complement appears to be pivotal for elimination of pathogens, not only as an early response defense, but by directing the subsequent adaptive immune response.
Instead, an increase in the steady-state levels of O2·− appears to be pivotal to inhibiting neurite outgrowth.
Glucose absorption is markedly diminished in the critically ill patient and downregulation of the sodium glucose co-transporter 1 appears to be pivotal [ 29, 35].
MMP-3 (stromelysin) appears to be pivotal in the activation of collagenases, whereas MMP-13 is crucial in collagen breakdown [ 28].
The behavior of the stroma appears to be pivotal for formation of follicles, and it is noteworthy that the follicles form first in areas where the stroma first contacts and partitions the ovigerous cords.
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