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In this study, using a decontamination protocol that clearly was effective for BACTEC (93.8% recovery rate of positive specimens, 7% contamination rate) does not appear to be optimized for the MGIT system (81.9% recovery rate, 18% contamination rate).
PpcA and PpcD appear to be optimized to interact with specific redox partners involving e−/H+ transfer via different mechanisms.
Ribosomes appear to be optimized for accurate and efficient translation of mRNA [ 34], and several examples of altered ribosome fidelity exist, both increasing [ 35] and decreasing fidelity [ 36].
The enzyme does not appear to be optimized to use the fastest pathway for on-enzyme chemistry preferentially but rather accesses multiple pathways in a search process that often selects slower ones.
LDH does not appear to be optimized to use mainly the fastest pathway, implying that the conformational search is not necessarily for one optimal pathway, but simply for an average pathway that is fast enough to satisfy the functional demands in the context of the cell.
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Copper retention, in contrast, appears to be optimized at an intermediate salinity consistent with brackish water, and therefore may release considerable fractions of retained copper at higher (e.g. seawater) salinity levels.
Copper retention, in contrast, appears to be optimized at an intermediate salinity consistent with brackish water, and therefore may release considerable fractions of retained copper at higher (e.g. seawater) salinity levels; copper retention also appears to become more variable and dependent on aggregation mechanism at these increasing salinities.
The genetic code appears to be optimized in its robustness to missense errors and frameshift errors.
Therefore, the fast kinetics of ChRGR appears to be optimized at pH 7.4.
The intrinsic dynamics of proteins appears to be optimized by evolution for functional interactions, yet the ligand selects the one that best fits its structural and dynamic properties among the conformations accessible to the unbound protein.
Self-regulation, including emotion regulation, appears to be optimized by a parent child relationship that has a mutually responsive orientation, meaning that interactions between parent and child are cooperative, coordinated, and harmonious, and involve the display of positive emotion [ 16, 40, 41].
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