Following the successful use of imatinib in CML, abnormal signaling pathways associated with myeloproliferation, be it the JAK-STAT pathway [ 126- 128] or another pathway, represent appealing targets.
Although the interpretation of negative and positive genetic interactions as relationships between and within pathways is appealing, it leaves large parts of the epistatic landscape completely unexplained.
The development of biocompatible collagen substrates able to conduct electric current along specific pathways represent an appealing issue in tissue engineering, since it is well known that electrical stimuli significantly affects important cell behaviour, such as proliferation, differentiation, directional migration, and, therefore, tissue regeneration.
Equally appealing are two others, "Winter Pathway," circa 1945, and "New England Winter," circa 1950's, both of which maintain the dewy freshness and spontaneity of the watercolor technique.
In this manner, a single miRNA can affect an entire signaling pathway, converting them into appealing tools for cell-fate conversion approaches.
Based on the findings described above, the potentially therapeutic strategy of blocking the IL-6 signaling pathway seemed logical and appealing.
Consequently, the use of anti-EGFR treatment with monoclonal antibodies could be at least theoretically inappropriate in these tumours, whereas the use of a treatment strategy including TKIs that can interfere with the EGFR downstream pathway could be more appealing.
The capability for visualizing data sets (e.g., gene expression levels) on pathways in Cytoscape is particularly appealing.
In contrast, inhibition of Pin1 could provide a unique way of disrupting oncogenic pathways and therefore represent an appealing target for anticancer therapies.
Particularly appealing is the over-representation of the KEGG pathways "Type II diabetes mellitus (T2D)" and "Insulin signaling pathway", which suggests a possible role of cell senescence in regulating insulin sensitivity and diabetes (Table 2).
