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Alba family proteins bind DNA cooperatively with no apparent sequence specificity.
Beyond the need for guide-target pairing, this "DNase H" activity has no apparent sequence requirements, and the cleavage sites are measured from the 5′ end of the DNA substrate's RNA-paired region.
"It seems clear that Ross lied to us, the latest in an apparent sequence of fibs, exaggerations, omissions, fabrications, and whoppers that have been going on with Forbes since 2004," the magazine wrote.
However, the protein NcrB has no apparent sequence similarity to these known transcript regulators.
The DAZ family proteins show apparent sequence variations in diverse organisms except for the RRM and DAZ motif.
All reported members of this family are basic proteins that exist as homodimers in solution and bind to DNA and/or RNA without apparent sequence specificity in vitro.
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Recently, Linsen and colleagues [28] discussed the apparent sequencing bias toward certain small RNAs thereby preventing the accurate determination of their absolute numbers.
Such widespread functions that occur independently of apparent sequence-specific DNA-binding proteins are referred to as 'global' histone modifications.
A more detailed analysis of this apparent sequence-specific hotspot for IS 6110 integration has recently been accepted for publication.
The absence of an apparent sequence-specific DNA-binding domain within components of the canonical PRC1 and PRC2 complexes has led to the proposal that transient transcription factor or non-coding RNA-based interactions may provide a mechanism for targeting to CGIs [ 35].
This apparent sequence-independent, progressive and directional enrichment along the Xist/ Tsix region indicates that, in the absence of Tsix transcription, the hotspot of H3K27me3 spreads into the Xist/ Tsix locus and, therefore, suggests that Tsix acts as a boundary element partitioning two distinct chromatin domains.
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