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Pharmacokinetic study of twice-daily (BID) JQ1 (50 mg/kg) confirmed excellent penetration of the blood:testis barrier and demonstrated a marked increase in drug exposure in the testis (AUC0 24hr = 96,640 hr∗ng/ml; Figure 3F and Table S4), accompanied by apparent partitioning into this compartment (AUCtestis/AUCplasma = 236%).
Parasites from Malawi and Tanzania were most consistently partitioned into distinct S GEG lineages and showed statistically significant divergence by Φ PT (0.42, p = 0.001) and R ST (0.436, p<0.0001) (Technical Appendix Table 2), visually apparent partitioning in an NJ network and in PCoA, and assignment to separate subpopulations in a probabilistic clustering algorithm.
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The apparent partition coefficient of MTZ was greatly reduced by the chemical modification.
The latter is usually expressed by the apparent partition coefficient log D in a biphasic system at physiological pH or by the affinity to a lipophilic phase determined by chromatographic techniques.
It is typically expressed as log P. The apparent partition coefficients of FA and FA PC in the n-octanol/water system were determined.
Moreover, three clusters are well observed in the glocal tree, while no apparent partition is detected in the BU tree.
The apparent partition coefficient Papp was calculated.
Next, the effect of pH on the apparent partition coefficients Papp of tetrandrine was assessed.
Greater variability in the apparent partition occurred at concentrations close to the detection limit.
Overall, tetrandrine exhibited the highest apparent partition coefficient at pH 7.0 for PBS.
For ionizable chemicals, differing compositions of the aqueous phases also generate multiple apparent partition coefficients, and this situation will be treated in section.
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