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While this may in part be because inhibitors clinically evaluated to date have not demonstrated clean inhibition of a single CDK, another contributing factor is an apparent latent functional redundancy in the CDK cell-cycle regulatory system.
Apparent latent periods of development of clinical bladder cancer may be as short as one, or as long as 50 years or more.
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Paratuberculosis caused by Mycobacterium avium subsp. paratuberculosis (MAP) is difficult to control due to a long phase of clinically non-apparent (latent) infection for which sensitive diagnostics are lacking.
The most famous of these purport to show that motion is impossible by bringing to light apparent or latent contradictions in ordinary assumptions regarding its occurrence.
Such an aggressive and invasive surgery must be a heavy burden in patients with impaired liver function, and long-term survival is seldom achievable because of apparent or latent pulmonary metastases in many patients with HCC-RA thrombus.
In addition, prognosis of patients with HCC-RA thrombus is extremely poor even in the case of complete removal of hepatic tumor and thrombus because most of the patients have apparent or latent pulmonary metastases.
In many cases they may not be apparent during a latent period which may last from months to years or decades.
These adverse effects, however, "may not be apparent during a latent period which may last from months to years or decades," and they can result from "a combination of developmental stressors…[that] cause effects jointly with similar or other exposures".
Currently, two challenges to the eradication of infection are apparent: the persistence of latent infection, and the persistent expression of low levels of virions from cells infected prior to ART initiation.
Due to measurement error α (which is assumed to be normally distributed), the apparent trait levels of latent class c varied from β c.
The model took the form: (1) φ cr = { 1 + exp [ − 1.7 α r (t ir − β c ] } − 1 where φ cr is the logistic cumulative density function of the apparent trait level of latent class c for observer r.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com