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In fish that had received exposure to estrogen before the exposure to the WwTW effluents, there was an apparent increase in the severity of the intersex condition, for both treatments and controls.
Although an obvious step forward, the clinical trial with ATRA did not immediately follow and it was only in 1987 that Huang and colleagues reported the successful use of ATRA to induce complete remission (CR) in patients with APL, without an apparent increase in the severity of the haemorrhagic diathesis observed at presentation (Huang et al, 1987).
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There was no apparent increase in the incidence or severity of AEs with escalating SC doses (Supplementary Table S2B; Wynne et al, 2013).
In general, the AZD9773 cohorts and placebo patients were comparable for safety and tolerability, and there was no apparent increase in the incidence or severity of AEs or changes in laboratory parameters with increasing exposure to AZD9773.
This has resulted in an apparent increase in the completion rate to 29% (as of 2006).
Surprisingly, the enhancement of para bss1 by chn was limited to BS paralysis recovery time phenotype, that is, an increase in the severity of this phenotype; there was no apparent enhancement of the other major phenotype: threshold for evoked seizure.
A sharp increase in the severity of sentencing has seen this number soar by 60% in a decade.
Admirers of the Rebus books will be relieved the hero has returned with little change except an increase in the severity of warnings from his doctor.
Other factors that may be contributing to this trend include an increase in the severity of specific injuries and more prolonged and comprehensive return to play protocols".
"Most patients with GERD experience an increase in the severity of symptoms (usually heartburn or coughing and choking) while sleeping or attempting to sleep," the organization states.
Moreover, the PDSI exhibited decreasing trends after 2005, indicating the apparent increase in drought severity.
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