This is particularly apparent from the high mortality rates due to pneumonia in the elderly (Office for National Statistics, 2005), and their susceptibility to hospital-acquired infections, such as Clostridium difficile and methicillin-resistant Staphylococcus aureus (Health Protection Agency, 2008).
On the contrary, high histologic grade and high proliferation rate are associated with worse prognosis but at the same time also predict for higher chemotherapy sensitivity, which is apparent from the higher rates of pathologic complete response to neoadjuvant chemotherapy and higher relative benefit from adjuvant chemotherapy among cancers with these molecular features.
The nucleotide position is fairly conserved in mammals (GERP score: -0.81) but has been subject to selection in humans as apparent from the high derived allele frequency (DAF ∈ 0.5 – 0.75) in all four HapMap populations and high linkage disequilibrium (LD) value (>1.4) in Asian and European populations [ 22].
Causal relationships of a large fraction of these genes with phenotypic variation is apparent from the high degree with which mutations in those candidate genes recapitulate effects on alcohol related phenotypes and from previous studies which have implicated the same genes in alcohol related phenotypes both in Drosophila and vertebrates, including mice and humans (Additional file 7).
We also chose to look at mortality in the patients given oxygen, as it was apparent from the high Charlson indices, poor lung function and ABG results that this population was very unwell, and reducing mortality is a key aim of LTOT use.
The classification is presented according to its correlation with apparent age, from the highest to the lowest.
Lead alone induced reactive gliosis which is apparent from the significantly higher expression of GFAP in all brain regions under study.
Many respondents did not have an opinion about the role of care providers in giving dietary advice, which was apparent from the relatively high number of blanks per item.
It is apparent from the rat studies that high maternal DES doses, especially if they started early in pregnancy, prevented implantation or caused miscarriage [ 20, 21], as is the case in humans [ 9].
Moreover, limited morphological differentiation among populations and ecosystems is also apparent, with the exception of those from the highest ecosystem of the Central Andes – the wet puna (hereafter, referred to as puna; Figure 1); note that ecosystems correspond to biophysically defined regions ([ 45]; see below for additional discussion between ecosystems and environmental conditions).
