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75 It appears that the differential effects of CBP/β-catenin antagonists on CSC versus normal SSC (i.e. forced differentiation and elimination versus differentiation and enhanced repair without apparent depletion) are apparently cell intrinsic and not due to the selective targeting by CBP/β-catenin antagonists of CSC versus normal SSC.
Of note is down-regulation of antigen presentation, antiviral responses and apparent depletion of T cells.
These findings indicate that elevated abundance of multiple, diverse microbial taxa within the Firmicutes and apparent depletion of Proteobacteria following FMT are significantly linked to alleviation of the inflammatory response and recovery of innate immune homeostasis.
Quantification of mtDNA in gray matter homogenate showed normal (n = 5) or moderately reduced (n = 2) mtDNA levels in adult patients and apparent depletion (∼20 30% of age-matched controls) in the children (Patients AL-1A and AL-1B).
Notably, however, such abundant biases in periplasmic proteins may explain the apparent depletion of pause in their N-terminal codons, likely due to the presence of N-terminal signal peptides.
The apparent depletion of the CPC at inner centromeres was confirmed by quantification of the fluorescence intensity levels for Aurora B. In each case, the level of Aurora B fluorescence was normalized to the level of staining seen for the corresponding centromere using ACA.
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We speculate that the apparent phosphate depletion might have been caused by an abundant phytoplankton community in the Columbia River in April (see below) under conditions of relatively high nitrate [34], low turbidity and high light.
Altered glucose consumption may also have therapeutic consequences: It became apparent that depletion of ATP by glycolytic inhibition potently induced apoptosis in multidrug-resistant cells in vitro [ 33, 35].
This poor correlation (i.e. apparent severe depletion of IIH6 epitope also in patients with relatively milder variants) may be due to the fact that there is some laminin-binding activity on α-dystroglycan owing to other glycans that are not recognized by IIH6 (McDearmon et al., 1998, 2001, 2003, 2006; Stalnaker et al., 2010, 2011).
Hardly any puncta were seen in resting cells expressing AARAE-V102C-Orai1-YFP AARAE-V102C-Orai1-YFP AARAE-V102C-Orai1-YFP AARAE-V102C-Orai1-YFP
Surprisingly, we faced an apparent conundrum, as depletion of uPA in these apoptosis-responsive cells enhanced cell death upon cytokine challenge.
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