Conversely, in the other three studies of sepsis and surgical patients that enrolled more severe patients, no substantial heterogeneity was observed, and PCT-based algorithm for discontinuation of antibiotics were associated with a significant reduction in antibiotic duration, without apparent deleterious effect.
The methoxyflurane fluoride nephrotoxicity threshold was largely surpassed without apparent deleterious effect on renal volume regulation and detoxification.
Deletion of HK2 has no apparent deleterious effect on normal tissues in mice, suggesting that HK2 inhibition could be used to treat HRV infection (common cold), for which there is currently no effective therapy.
The combination regime leads to permanent eradication of established tumours in all co-treated animals with no apparent deleterious side-effects.
Viral transduction, luciferase expression, and repeated imaging had no apparent long-term deleterious effects on islet function after implantation.
It is difficult to reconcile the apparent conflict in beneficial versus deleterious effects of estrogen on neurological and vascular function unless the effects of age are considered.
The present study was designed to further define the origin of the mitochondria impairment and to understand the apparent lack of deleterious effect on the heart.
Deleterious effects are most apparent when stress has been prolonged, whereas in contrast the acute response to a stressor is adaptive with increased attention, vigilance and improved cognitive performance (de Kloet et al., 1999; Joels et al., 2008, 2011; Sandi, 2011).
Most of the studies examining the effect of PAF on immune function and carcinogenesis suggest it has a negative effect, so the evolutionary advantage of daily release of this inflammatory mediator that has such deleterious effects is not readily apparent.
In recent years, it has become apparent that the environmental presence of chemicals that mimic natural hormones can have deleterious effects on reproduction in ecologic species.
