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Apparent clearance was 120 L/h.
Apparent clearance increased during the first year of life, with a break point at 2 months of age (mean, 0.119 ± 0.021, 0.217 ± 0.094 L/h per kilogram for infants <2 months and those 2 to 12 months old, respectively,P <.001).
Estimated clearance is the apparent clearance CL/f where f is the fraction of osetlamivir absorbed and converted to OC.
Apparent clearance (CLapp) calculated as Dose/AUC.
Apparent clearance was dependent on AAG levels and bodyweight.
26 However young infants have a higher apparent clearance of drugs and altered absorption.
Furthermore, no relationship between haplotypes for ABCB1 genotypes and apparent clearance was found.
Apparent clearance was corrected for the fraction of the dose that was metabolised (CL/ fm).
Multiplying the day 1 apparent clearance (dose/AUCday 1) by Fa to negate the effect of changes in absorption, the adjusted apparent clearance (CLadjusted = Fa × dose/AUCday 1) decreased from 11.3 to 7.3 L/h over the dose range.
The apparent clearance and apparent volume of distribution of apremilast were both lower after co-administration with ketoconazole (Table 1).
In this renal study, mean apparent clearance in the mild RI group was higher than in the healthy control group.
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