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This apparent bottleneck in transfer from biomarker discovery to clinical application is primarily due to a lack of rigorous validation of emerging biomarkers.
Although Thr348 and Ser607 are located at apparent bottleneck regions and Asp778 points toward the middle of the channel, substitutions of these residues with Tyr did not impact PRODH P5CDH channeling activity in BjPutA.
An apparent bottleneck exists around the pyruvate node in C. thermocellum metabolism, and amino acid and C4-solvent production could be a strategy to channel away catabolic intermediates in an attempt to maintain a balanced metabolism.
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There is little attention to the apparent system bottleneck which is the sensor operator and imagery analysts, at the pointy end of the stick, pouring over screens of video data 24/7.
Instead of a single ensemble distribution for the whole sample, it becomes apparent where bottlenecks and wide-pore regions are.
Levels of HIV-1 in these transmitting compartments (e.g., genital fluids and breast milk) are usually much lower than those in blood [14], [15], [16], but few studies have addressed how mucosal restriction contributes to the apparent transmission genetic bottleneck.
However, yields above 20% have not yet been realized owing to bottlenecks that become apparent in the endogenous biosynthetic pathways when heterologous genes are expressed.
In this study, the genetic diversity of six key genes in the starch pathway was investigated in a glutinous population that included 55 Chinese waxy accessions, and a selective bottleneck that resulted in apparent reductions in diversity in Chinese waxy maize was observed.
The health financing bottlenecks described were especially apparent in interventions related to mothers and newborns with complications requiring extra care.
Examination of ancient sequences in the domestic species might reveal a more complex pre-domestication bottleneck demographic history than the apparent constant population size shown here.
This programme tests for a relative excess in heterozygosity that is apparent for a few generations after a bottleneck and develops because allelic diversity declines faster than heterozygosity, due to loss of rare alleles.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com